Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development\r\nand progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology\r\nof white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the\r\ndevelopment of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular\r\nand molecular mechanisms at play in osteoarthritis elicited by adipokines.We also emphasize how defining the role of adipokines\r\nhas broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of\r\nmodifying it to prevent and treat diseases.
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